AGARIC Case Control Study

University Hospital Center (CHU) Dijon Bourgogne

Status

Unknown

Conditions

First Recently-diagnosed Colorectal Cancer

Treatments

Other: Blood sample

Other: tissue samples from abdominal subcutaneous adipose

Study type

Interventional

Funder types

Other

Identifiers

NCT01966081

Bonithon hors AOI 2008

Details and patient eligibility

About

The aim of the study is to establish the existence of a relationship between the dietary intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans, using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of the abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte phospholipids.

Enrollment

576 estimated patients

Sex

All

Ages

45+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

CASES

Patients aged ≥ 45 years
with a first recently-diagnosed colorectal cancer
due to undergo elective surgical resection with curative intent (in practice, stage I, II, III or IV if there was only one hepatic nodule that was resected with curative intent) in one of the 5 following digestive surgery units: CHU de Dijon, CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon.
who have given their informed consent

CONTROLS

Patients aged ≥ 45 years
due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis, appendectomy, hiatal hernia ...)
matched for abdominal site with cases for age (± 3 years), sex and hospital
Who have given their informed consent

Exclusion criteria

CASES

pre-operative anticancer treatment (chemo or radiotherapy)
existence of visceral metastases except a single hepatic nodule resected with curative intent
familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after complementary tumor phenotype study: screening for microsatellite instability and/or immunohistochemistry study of the expression of DNA mismatch repair proteins.
known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)
personal history (recent or not) of colorectal cancer
emergency treatment for the presenting complication (perforation, occlusion...)
significant modification in dietary habits during the previous three months
other evolving neoplastic disease
psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship)
pregnant or breast-feeding women

CONTROLS

personal history of cancer or adenomatous colorectal polyps,
emergency intervention
known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)
personal history (recent or not) of colorectal cancer
emergency treatment for the presenting complication (perforation, occlusion...)
significant modification in dietary habits during the previous three months
evolving neoplastic disease
psychic state incompatible with understanding the modalities and the aims of the study (notably patients under guardianship)
pregnant or breast-feeding women