Age and Gender Corrected Body Mass Index

University Hospital, Gasthuisberg

Status: Unknown

Conditions: Esophageal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01958697

AG-BMI

Details and patient eligibility

About

Esophagectomy for cancer is often accompanied with severe preoperative weight loss. Body Mass Index (BMI) values are age-independent and the same for both sexes. From the perspective that these two parameters should actually be taken into account too, we developed a model to calculate "age-gender specific BMI-percentiles" (AG-BMI) and tested this model in relation to survival outcome after esophagectomy for cancer.

Full description

Age-Gender specific BMI percentiles are more accurate compared to the current BMI classes in predicting Overall Survival (OS) after esophagectomy for cancer. Furthermore we believe in a more devastating impact on OS from underweight and not from overweight.

By preoperatively identifying risk patients for poorer OS, especially the non-tumoral deaths, this can be a tool to tailor postoperative nutritional strategies to counter further weight loss and bringing postoperative weight to normal ranges.

Enrollment: 650 estimated patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• any type of esophagectomy

Exclusion criteria

• Preoperative organ metastasis (cM+ or yM+)
• esophageal bypass surgery

Trial design

650 participants in 2 patient groups

AG-BMI < 10 pct

Description:

Patients who's peroperative BMI is less than the 10th centile

AG-BMI >= 10th pct

Description:

Patients who's peroperative BMI equals or is greater than the 10th centile