AGE - Functional Reserve (AGE-FR)
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About
Renal functional reserve is defined as the glomerular hyper filtration induced by a protein load. Renal blood flow and Glomerular Filtration Rate (GFR) increase in response to a protein load. Renal functional reserve loss is associated with a persistent hyper filtration state, seen in first stages of diabetic nephropathy, leading to progression of Chronic Kidney Disease (CKD). This observation has lead to larger clinical studies that demonstrated the positive effects of protein restriction on kidney function, and allowed the scientific community to recommend low proteins diet (less than 0.8 g / kg/ day) to prevent CKD progression. Nevertheless, the precise mechanisms responsible for kidney hemodynamic and metabolic changes induced by a protein load, are debated. Uribarri et al have suggested that renal hemodynamic changes induced by a protein load are mainly due to the Advanced Glycation End Products (AGEs) content. Indeed, initial studies experimental conditions leading to the demonstration of renal functional reserve (amino acid or protein perfusion or cooked meat), were in fact responsible for an AGEs load, based on recent published data.
The aim of this study is to determine whether AGEs alone or proteins in general are responsible for the mobilization of renal functional reserve, leading to the progression of CKD.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Healthy males subjects
- age between 18 and 30 years old
Exclusion criteria
- Kidney disease
- Diabetes
- Obesity
- Hypertension
- Non Steroidal Anti Inflammatory Drug treatment (NSAIDS)
- MRI Contra indications
- Myeloma
- High basal Radiation exposure : more than 1 milliSievert (mSv) in the last 6 months
Trial design
Primary purpose
Allocation
Interventional model
Masking
10 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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