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The overall objective is to evaluate the effect of exposure to Plasmodium (P.) falciparum erythrocytic stage antigens during different periods of infancy on the development of naturally acquired immunity (NAI).
Hypothesis: Exposure to P. falciparum prior to 5 months of age does not result in the development of NAI, while exposure to P. falciparum after 5 months of age leads to the development of NAI. The risks of clinical malaria and anaemia during the second year of life will be compared between cohorts, as well as their correlations with the type and quality of immune responses (antibodies to several P. falciparum antigens, cytokines), oxidative stress markers and host genetic factors. These results should shed light on the determinants of the development of anti-P. falciparum responses early in life and the potential constraints to early life immunisation.
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Inclusion criteria for pregnant women:
Inclusion criteria for newborn infants:
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Exclusion criteria for pregnant women:
Exclusion criteria for newborn infants:
349 participants in 3 patient groups, including a placebo group
There are currently no registered sites for this trial.
Start date
Sep 01, 2005 • 19 years ago
End date
Mar 01, 2009 • 15 years ago
Today
Jan 20, 2025
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Data sourced from clinicaltrials.gov
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