Age of Red Blood Cells in Premature Infants Study (ARIPI)

Ottawa Hospital Research Institute

Status: Completed

Conditions: Premature Birth

Treatments: Biological: Transfusion

Study type: Interventional

Funder types: Other

Identifiers

NCT00326924

2004706-01H

Details and patient eligibility

About

To determine if the age of blood transfused to new borns in the NICU setting has an impact on their outcome.

Enrollment: 377 patients

Sex: All

Ages: 1 minute to 37 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• birthweight of less than 1250g
• admitted to participating NICU
• consent acquired from proxy for the patient

Exclusion criteria

• already received one or more transfusions
• requirement for an exchange transfusion
• will be receiving directed donations
• have rare blood types/difficult cross-match
• proxy has refused consent
• moribund on admission to NICU/expected to die
• mitigating child protection issues

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

377 participants in 2 patient groups

Biological

Experimental group

Description:

PRBCs that are less than 7 days old are considered 'fresh'.

Treatment:

Biological: Transfusion

Standard PRBCs

Experimental group

Description:

PRBCs 'stored' as per hospital policy.

Treatment:

Biological: Transfusion