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Age-Related Changes in Sleep-Dependent Emotional Memory

University of Massachusetts, Amherst logo

University of Massachusetts, Amherst

Status

Unknown

Conditions

Emotional Valence
Age
Sleep

Treatments

Behavioral: Overnight sleep
Behavioral: Wake

Study type

Interventional

Funder types

Other

Identifiers

NCT04141722
1R56AG058685-01

Details and patient eligibility

About

Memory influences emotional well being. Research has shown that having a negative emotional bias contributes to both emotion dysregulation and depression. Conversely, reactivating positive memories has been shown to reduce stress and symptoms of depression. In young adults, sleep is widely implicated in emotional processing, including consolidation of emotional memories. Evidence suggests that aging is associated with changes in emotion, including a positive memory bias and enhanced emotional well-being. These changes have been termed the "age-related positivity effect." However, the influence of sleep on these measures has not been investigated in healthy older individuals. The objective of this research is to understand the role of sleep in emotional memory consolidation and emotional well-being across adulthood. We hypothesize that sleep contributes to the age-related positivity effect in memory and affect. Our alternative hypothesis is that age-related decreases in sleep are responsible for reduced emotional memory processing over healthy aging.

Enrollment

80 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • 18-30 or 50-80 years of age
  • Have no history of a sleep disorder
  • Have no history of neurological disease or injury
  • Have no history of psychiatric illness (anxiety or mood disorder, schizophrenia, etc.)
  • No history of chemotherapy
  • Not be taking medications which effect sleep
  • Habitually sleep more than 6 or more hours per night
  • Be able to walk freely and independently
  • Have normal to corrected-to-normal vision

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

80 participants in 2 patient groups

Sleep
Experimental group
Treatment:
Behavioral: Overnight sleep
Wake
Experimental group
Treatment:
Behavioral: Wake

Trial contacts and locations

1

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Central trial contact

Rebecca Spencer

Data sourced from clinicaltrials.gov

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