Age-related Changes in Sleep-wake Regulation

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Sleep Deprivation

Treatments

Behavioral: Prolonged wakefulness

Study type

Interventional

Funder types

Other

Identifiers

NCT03813082
PSS-Sleep

Details and patient eligibility

About

A sleep deprivation protocol combined with state-of-the-art, simultaneous positron emission tomography and magnetic resonance spectroscopy imaging will be employed to investigate the effects of sleep deprivation and aging on hypothesized molecular markers of sleep need.

Enrollment

29 patients

Sex

Male

Ages

20 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy male individuals
  • age: 20-35 or 60-70 years
  • right-handed
  • non-smokers
  • moderate caffeine/alcohol consumption
  • normal BMI

Exclusion criteria

  • Sleep/circadian rhythms disturbances
  • former brain injuries with loss of consciousness and brain anomalies
  • drug intake/consumption
  • medication intake
  • cardiac pacemaker
  • neurological disorders
  • prior participation (during past 2 years) in radiological or nuclear experiment

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

29 participants in 2 patient groups

Sleep deprivation young men
Experimental group
Description:
Young study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep.
Treatment:
Behavioral: Prolonged wakefulness
Sleep deprivation older men
Experimental group
Description:
Older study participants will complete four nights in the sleep laboratory, whereas they will stay awake during one night. PET brain imaging will be conducted at the same circadian time on three consecutive afternoons (prior, during and after prolonged wakefulness). Additionally, validated tests of vigilance and cognitive performance will be administered and the brain waves will be recorded in wakefulness and sleep.
Treatment:
Behavioral: Prolonged wakefulness

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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