Age-related Differences in Response to Pituitary Stimulation Tests

Aalborg University Hospital

Status

Completed

Conditions

Aging

Pituitary

Treatments

Diagnostic Test: Pituitary stimulation test

Study type

Observational

Funder types

Other

Identifiers

NCT04572139

N-20200008

Details and patient eligibility

About

The purpose of this study to age-related differences to the response of a combined pituitary stimulation test with TRH, LHRH and ACTH.

Full description

Participants will be recruited in three different age intervals: 18-45 years, 55-80 years and 80+ years. These participants will all undergo the same stimulation test with 0.1 mg LHRH, 0.2 mg TRH, and 0.25 mg ACTH (Synachten). The tests will be perfomed at the same time of day for all particpants (between 08:15 and 08:45) and participants will be fasting for the test. Blood samples will be taken just before and at 10, 20, 30, 45, 60, 90 and 120 minutes following the stimulation test. Serum from blood samples will be stored at -20 degrees until analysis.

Enrollment

25 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ages between 18-45 or above 55.
Healthy Volunteers

Exclusion criteria

Medication or conditions affecting pituitary response (such as hormonal birth control, steriod use, thyroid disorders)
Pregnancy or birth within the last year
inability to give informed consent