Aggressive Onset Multiple Sclerosis: A Practical Definition and Study of Its Clinical Course

Weill Cornell Medicine (WCM)

Status: Completed

Conditions: Multiple Sclerosis

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02301572

0711009544

Details and patient eligibility

About

Chart review.

Full description

A chart review will be completed on patients with multiple sclerosis to determine potential early characteristics that might be helpful in defining aggressive onset MS and predicting subsequent disease course and disability

Enrollment: 750 patients

Sex: All

Ages: Under 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Two or more relapses in the preceding year and 2 or more gadolinium enhancing lesions on brain MRI scan or a significant T 2 lesion burden or
• One relapse if it results in sustained EDSS of 3.0 along with 2 or more gadolinium enhancing lesions or significant T2 lesion burden ( T2 lesion burden being determined by factoring the number of lesions, the size of the lesions and lesion location)

Exclusion criteria

Trial design

750 participants in 1 patient group

Aggressive onset MS

Description:

Two or more relapses in the preceding year and 2 or more gadolinium enhancing lesions on brain MRI scan or a significant T 2 lesion burden or One relapse if it results in sustained EDSS of 3.0 along with 2 or more gadolinium enhancing lesions or significant T2 lesion burden ( T2 lesion burden being determined by factoring the number of lesions, the size of the lesions and lesion location)