Aggressive Versus Moderate Glycemic Control in Diabetic Coronary Bypass Patients

American Heart Association (AHA)

Status and phase: Completed; Phase 1

Conditions: Glycemic Control

Treatments: Drug: Insulin; Drug: IV Insulin drip

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00576394

H-25760

Details and patient eligibility

About

entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control (120-180mg/dl) will further improve outcomes.

Full description

150 diabetic patients will be randomized to achieve aggressive glycemic control (80-120mg/dl) vs moderate control (120-180mg/dl) using intravenous insulin infusions beginning at anesthetic induction and continuing for 18 hours following surgery.

Enrollment: 108 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All diabetic patients undergoing Coronary Bypass Surgery

Exclusion criteria

• Patients with hepatic and renal failure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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108 participants in 2 patient groups

1Moderate Glycemic Control

Active Comparator group

Description:

Patients will receive an insulin drip to keep blood glucose levels between 120-180mg/dl

Treatment:

Drug: IV Insulin drip

2Aggressive Glycemic Control

Active Comparator group

Description:

Patients will receive an insulin drip designed to maintain serum glucose between 80-120mg/dl

Treatment:

Drug: Insulin