Aging, Aged Garlic, Vascular Function and Muscle Oxygenation

Universidade Federal do Rio de Janeiro

Status: Completed

Conditions: Hypertension; Aging; Abdominal Obesity; Dyslipidemias

Treatments: Other: Placebo; Dietary Supplement: Aged Garlic Extract

Study type: Interventional

Funder types: Other

Identifiers

NCT04008693

86163618.5.0000.5699

Details and patient eligibility

About

The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.

Enrollment: 28 patients

Sex: All

Ages: 60 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cardiometabolic risks
• Cardiovascular diseases

Exclusion criteria

• Cancer;
• HIV positive;
• Alcohol or drug abuse within the past 6 months previous the visit 1;
• Garlic allergy;

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

28 participants in 2 patient groups, including a placebo group

Kyolic® Hi-Po Formula - Kyolic

Active Comparator group

Description:

Aged garlic extract

Treatment:

Dietary Supplement: Aged Garlic Extract

Placebo

Placebo Comparator group

Description:

Maltodextrin

Treatment:

Other: Placebo