Aging of the Vascular Wall (VITAL)

Centre Hospitalier Universitaire de Saint Etienne

Status: Enrolling

Conditions: Aging Disorder; Vascular Risk

Treatments: Procedure: Graft collection

Study type: Observational

Funder types: Other

Identifiers

NCT07122427

IRBN502025/CHUSTE

Details and patient eligibility

About

Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs. This decline in function increases the risk of numerous diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases (CVD). CVD, the leading global cause of death, becomes more prevalent with age. Aging contributes to endothelial dysfunction, vessel stiffness, thickening, and impaired platelet function. These changes disrupt hemostatic processes and increase the risk of cardiovascular complications. Despite preventive strategies CVD remain a major public health challenge. Cellular aging, or senescence, affects all cell types, particularly endothelial cells and platelets. However, little research has compared the aging rates of different blood vessel types, such as arteries and veins. Given their distinct compositions and developmental origins, it is likely that their aging processes differ at molecular, cellular, and physiological levels.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major patients requiring coronary artery bypass grafting (CABG).

Exclusion criteria

• Hypertension, diabetes, systemic inflammatory disease.

Trial design

30 participants in 3 patient groups

Youngs

Description:

Patients aged 18 to 30 requiring coronary artery bypass grafting (CABG).

Treatment:

Procedure: Graft collection

Middle-aged

Description:

Patients aged 30 to 60 requiring coronary artery bypass grafting (CABG).

Treatment:

Procedure: Graft collection

Elderly

Description:

Patients aged 60 and more requiring coronary artery bypass grafting (CABG).

Treatment:

Procedure: Graft collection