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The ANRS ( Agence Nationale de Recherches sur le Sida et les Hépatites virales) 0093s Aging HAND study is to assess whether PLHIV (People Living with HIV) initially between 55-70 years of age at baseline analysis under antiretroviral therapy have accelerated decline of neurocognitive function after 6 years of follow-up.
Aging HAND is a French, multicentric, longitudinal, transversal, prospective study with inclusion of 290 PLHIV.
Full description
The primary objective of this study is to analyze whether PLHIV initially aged between 55-70 years of age at baseline under antiretroviral therapy have accelerated decline of neurocognitive function after 6 years of follow-up in comparison with an age, gender and educational level matched HIV non-exposed control group from the CONSTANCES cohort.
The secondary objectives of this study are :
To determine the prevalence of neurocognitive impairment (NCI) according to the Frascati criteria, clinical consensus and alternative classifications, after additional accrual of individuals aged 55 to 76 years for a more precise and extensive age range analysis of NCI To describe the incidence and prevalence of the frailty syndromes, and their relation with co-morbidities and NCI, using the Fried score as a measure of frailty To constitute a plasma and serum biobank for biomarkers study related to the aging of PLHIV
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Inclusion and exclusion criteria
Inclusion criteria
Inclusion criteria for PLHIV for the longitudinal study:
Inclusion criteria for PLHIV for the transversal study (only for new subjects):
Exclusion criteria
Non-inclusion criteria for PLHIV for both the longitudinal and transversal studies:
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Interventional model
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290 participants in 1 patient group
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Central trial contact
Faroudy Boufassa; Valérie Andriantsoanirina
Data sourced from clinicaltrials.gov
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