ClinicalTrials.Veeva

Menu

Agonist Gonadotropin-Releasing Hormone (GnRH) Versus Antagonist GnRH

Y

Yazd Research & Clinical Center for Infertility

Status and phase

Unknown
Phase 3

Conditions

Infertility

Treatments

Drug: suprefact
Drug: ganirelix

Study type

Interventional

Funder types

Other

Identifiers

NCT00823602
1387YAZDRCCI

Details and patient eligibility

About

Literature suggests that GnRH antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. Up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique.

This prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of ART.

The investigators will randomize 160 patients undergoing ART for the first time . Group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with GnRH antagonist and then result of ART compare in two group .

Enrollment

2 estimated patients

Sex

Female

Ages

Under 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • first cycle of ART
  • age < 35 years
  • basal FSH < 10 IU/L

Exclusion criteria

  • previous IVF or ICSI, hyperprolactinemia, hyperthyroidism, hypothyroidism, uterine abnormality, severe endometriosis
  • only one ovary

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

2 participants in 2 patient groups

1
Experimental group
Description:
GnRH antagonist "ganirelix" 0.25 mg fromm 6th ovarian stimulation
Treatment:
Drug: ganirelix
2
Active Comparator group
Description:
GnRH agonist, suprefact, stimulation with a standard long protocol
Treatment:
Drug: suprefact

Trial contacts and locations

1

Loading...

Central trial contact

shahnaz Ahmadi, MD; razieh firouzabadi, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems