Agouti-related Peptide (AgRP) in Healthy Mothers and Mothers With Preeclampsia and Their Offspring

Masaryk University

Status: Completed

Conditions: Preeclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT01042210

MU-JBV-PPM1

Details and patient eligibility

About

The study is focused on the investigation of possible associations between plasma/serum levels of agouti related peptide (AgRP) and its genetic background in healthy women with physiological pregnancy (non-preeclamptic) and women with preeclampsia, in the postpartum period, and in their offspring.

Full description

The study is focused on investigation of possible genotype-phenotype interactions of agouti-related peptide (AgRP) in postpartum non-preeclamptic women and preeclamptic women and in their offspring.

Enrollment: 84 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• For preeclampsia:

  • development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (>300 mg of urinary protein/L over 24 h)
  • single-fetus pregnancy
  • age range 18-35 y
  • no preconceptional history of hypertension

• For mother with physiological pregnancies:

  • uncomplicated
  • spontaneous conception
  • single-fetus pregnancy
  • age range 18-35 y
  • spontaneous uncomplicated delivery
  • no history of preconceptional hypertension

Exclusion criteria

• For preeclampsia:

  • multiple pregnancy
  • preeclampsia superimposed to chronic hypertension preceding pregnancy
  • kidney disease
  • fetal malformations

• For mothers with physiological pregnancies:

  • in vitro fertilization
  • fetal malformations
  • multiple pregnancy
  • events of bleeding

Trial design

84 participants in 4 patient groups

Mothers, preeclampsia

Description:

Mothers with preeclampsia diagnosed according to the Guidelines by the Czech Society of obstetrics and gynecology as development of hypertension after the 20th week of pregnancy (systolic blood pressure, ≥140 mmHg; and/or diastolic blood pressure, ≥90 mmHg; measured at rest on two consecutive occasions at least 24 h apart) in previously normotensive women, and the onset of proteinuria (\>300 mg of urinary protein/L over 24 h).

Newborns, physiological pregnancy-delivery

Description:

The newborns from the physiological pregnancies with spontaneous, uncomplicated delivery.

Newborns, pregnancy with preeclampsia

Description:

Newborns from the pregnancies complicated by preeclampsia.

Mothers, Physiological pregnancy-labour

Description:

The cohort of non-preeclamptic mothers with physiological, uncomplicated conception, pregnancy and delivery.