AGR+PNI as Predictors of Systemic Lupus Erythematosus Disease Activity

Sohag University

Status: Not yet enrolling

Conditions: Systemic Lupus Erythematosus Disease

Treatments: Diagnostic Test: Albumin to globulin ratio and prognostic nutritional index model

Study type: Observational

Funder types: Other

Identifiers

NCT07043153

Soh-Med--25-6-1MS

Details and patient eligibility

About

This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.

Enrollment: 140 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• · Age ≥ 18 years.

  • Both sexes.
  • Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.

Exclusion criteria

• Co-existing chronic inflammatory or autoimmune diseases.
• Age <18 years
• Malignancy.
• Pregnancy or lactation.
• Chronic liver or renal insufficiency.
• Malignant hematologic diseases.
• Active hepatitis.
• Acute infection within the previous four weeks

Trial design

140 participants in 2 patient groups

Active SLE group:patients with active (SLE), fulfilling the ACR/EULAR classification criteria,

Treatment:

Diagnostic Test: Albumin to globulin ratio and prognostic nutritional index model

Healthy controls:Age and sex-matched healthy individuals without any history of autoimmune diseases

Treatment:

Diagnostic Test: Albumin to globulin ratio and prognostic nutritional index model