AI-driven Clinical Decision Support for Perioperative Blood Orders (SPATH)

The Washington University

Status: Enrolling

Conditions: Surgery

Treatments: Other: S-PATH clinical decision support system; Other: Usual care

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07223853

202506199

K23HL166880 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Clinician Level Exclusion Criteria:

• Clinician (resident physician or advanced practice provider) who works at a preoperative assessment clinic

Clinician Level Exclusion Criteria:

• None

Patient Inclusion Criteria:

• Scheduled for surgery in one of the main operating room areas (non-remote) at Barnes Jewish Hospital
• Evaluated in-person at one of the preoperative assessment clinics affiliated with BJC Healthcare
• Have a valid S-PATH model prediction prior to their preoperative assessment clinic visit

Patient Exclusion Criteria:

• Pregnant
• Presence or history of red cell alloantibodies

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Usual care

Active Comparator group

Description:

Usual care for determining presurgical blood orders, including use of the institutional Maximum Surgical Blood Ordering Schedule (MSBOS)

Treatment:

Other: Usual care

S-PATH

Experimental group

Description:

Access to the S-PATH clinical decision support system

Treatment:

Other: S-PATH clinical decision support system