Air Pollution and Health of COPD Patients

Peking University

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: Air pollutants

Study type: Observational

Funder types: Other

Identifiers

NCT05076630

IRB00001052-21085

Details and patient eligibility

About

This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.

Full description

This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.

Enrollment: 110 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• doctor-diagnosed stable COPD patients
• aged 40 to 80 years
• lived in Beijing for over one year before being recruited
• Agree to participate and sign the informed consent form.

Exclusion criteria

• Patients with a history of acute exacerbation in the last 1 month
• Patients with other respiratory diseases such as bronchiectasis and asthma.