Air Pollution, Inflammation and Acute Coronary Syndrome (AIRACOS)

Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Status: Completed

Conditions: Patients With Acute Coronary Syndrome

Treatments: Other: Particulate air pollutants

Study type: Observational

Funder types: Other

Identifiers

NCT01799148

AIRACOS

AIRACOS-CANARY ISLANDS (Other Identifier)

Details and patient eligibility

About

The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.

Enrollment: 307 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with acute coronary syndrome

Exclusion criteria

• Infectious process and / or local or systemic inflammation in the 15 days before admission.
• Thyrotoxicosis.
• Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

Trial design

307 participants in 1 patient group

Particulate air pollutants

Description:

Cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.

Treatment:

Other: Particulate air pollutants