Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools (proto nage)

Laval University

Status: Unknown

Conditions: Airway Hyperresponsiveness; Asthma

Study type: Observational

Funder types: Other

Identifiers

NCT00686452

CER20159

Details and patient eligibility

About

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

1. to compare the prevalence of asthma in swimmers and control subjects
2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Enrollment: 100 estimated patients

Sex: All

Ages: 14 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 14 to 35 years old
• To swim at least 10h per week
• For control subjects, non-competitive healthy subjects

Exclusion criteria

• any disease that may interfere with the tests for the controls
• Triathletes are excluded
• Smokers
• Obese or with a BMI more than 29
• Former athletes (control group)

Trial design

100 participants in 7 patient groups

1

Description:

Swimmers without AHR

2

Description:

Swimmers with asymptomatic AHR

3

Description:

Swimmers with symptomatic AHR and use only of beta-2 adrenargic

4

Description:

Swimmers with asthma and inhaled corticosteroids

5

Description:

Healthy Subjects

6

Description:

Healthy subjects with AHR

7

Description:

Healthy subjects with symptomatic AHR (asthma) but without treatment