Airway Inflammation, Symptoms and Lung Function in COPD

Università degli Studi di Ferrara

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: COPD treatment

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01216592

ISLCOPD01

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease with high prevalence worldwide and with relevant impact on patient-related quality of life, morbidity and mortality. There is evidence that airway inflammation correlates with the severity of the disease and that airway inflammation is further enhanced during exacerbation. However, it is unknown whether daily fluctuation of symptoms or changes in lung function is paralleled by changes in airway inflammation.

Full description

Patients will undergo a visit every 7 days during one month (5 visits in total). At each visit airway inflammation (exhaled NO, sputum inflammatory cell count) and lung function will be performed. At home patients will be asked to fill a daily diary for symptom assessment.

Enrollment: 40 patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Post-bronchodilator FEV1/FVC ratio < 70%
• Post-bronchodilator FEV1 < 80%
• Smokers or ex-smoker with pack/years > 15

Exclusion criteria

• Atopy
• Asthma
• Concomitant lung diseases (e.g. lung cancer)
• Acute infections of the respiratory tree in the previous 2 months including COPD exacerbation.

Trial design

40 participants in 1 patient group

COPD

Treatment:

Other: COPD treatment