Airway Pressure During Nasal High Flow and CPAP in Neonates

Research Center of Maternal and Child Health Protection, Armenia

Status: Completed

Conditions: Respiratory Insufficiency

Treatments: Device: CPAP; Device: NHF big cannula; Device: NHF small cannula

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02632799

RCMCHP012

Details and patient eligibility

About

Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes. The aim of the study was to investigate airway pressure during NHF and CPAP in neonates.

Full description

Methods: A physiological study which measured pressure intra-nasally with micro (750 µm) pressure probes (Millar, USA) in 10 (5M / 5F) healthy newborns with mean gestation age 37.18 (SD 1.29) wk and mean birth weight of 2414 (SD 503.13) g. NHF was applied at 8 L/min (AIRVO 2) through smaller (OPT 314) and larger (OPT 316) Optiflow nasal cannula; CPAP 5 cmH20 was produced by a Bubble CPAP system and nasal mask interface at constant flow 8 L/min (Fisher & Paykel Healthcare, NZ). Values are expressed in cmH20 as means and standard deviations (SD).

Enrollment: 10 patients

Sex: All

Ages: 1 to 3 days old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy term newborns

Exclusion criteria

• Newborns with any medical problems after birth
• Absent of parents consents

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

10 participants in 4 patient groups

NHF small cannula

Experimental group

Description:

NHF 8 L/min (Airvo2) , Smaller cannula (neonatal, yellow)

Treatment:

Device: NHF small cannula

NHF big cannula

Experimental group

Description:

NHF 8 L/min (Airvo2) , Bigger cannula (neonatal, purple)

Treatment:

Device: NHF big cannula

Mask CPAP

Experimental group

Description:

CPAP 5cm H2O

Treatment:

Device: CPAP

no intervention

No Intervention group

Description:

control