Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma

University of Saskatchewan

Status: Completed

Conditions: Atopic Asthma

Treatments: Drug: Placebo; Drug: ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT02327234

Bio REB 14-283

Details and patient eligibility

About

The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.

Enrollment: 13 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of mild asthma, currently well controlled requiring only a bronchodilator (e.g. salbutamol) as needed and infrequently
• has allergies that trigger asthma
• responds to methacholine challenge at 16mg/ml or less
• has FEV1 > 69.5% predicted

Exclusion criteria

• respiratory illness within 4 weeks
• other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data
• pregnant or lactating females
• hypersensitivity to ibuprofen

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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13 participants in 2 patient groups, including a placebo group

Ibuprofen

Experimental group

Description:

400mg (2X200mg) ibuprofen single dose once

Treatment:

Drug: ibuprofen

Placebo

Placebo Comparator group

Description:

identical appearing lactose capsules single dose 2 capsules once

Treatment:

Drug: Placebo