Airway Responses to Montelukast and Desloratadine.

University of Saskatchewan

Status: Completed

Conditions: Asthma

Treatments: Drug: Montelukast (10mg) and Desloratadine (5mg)

Study type: Interventional

Funder types: Other

Identifiers

NCT00424580

BIO-REB# 06-232

Details and patient eligibility

About

Montelukast (for asthma) and desloratadine (for allergies) are effective therapy for their current uses. Part of what happens when your allergies trigger your asthma should be prevented by either of these drugs. This project is being conducted to determine if these drugs are effective, either alone or in combination, on controlling asthma that is triggered by allergies.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• baseline FEV1 > or = 65% predicted
• positive methacholine challenge (i.e. methacholine PC20 < or = 16mg/ml
• positive allergen challenge

Exclusion criteria

• negative skin prick test
• lung condition/disease other than asthma
• currently use montelukast and/or desloratadine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind