Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

snow

Status: Unknown

Conditions: Lung Disease,Obstructive

Treatments: Drug: No drugs; Drug: Salbutamol Aerosol

Study type: Interventional

Funder types: Other

Identifiers

NCT02592122

2013-10-COPD

Details and patient eligibility

About

In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

Enrollment: 120 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute exacerbation of chronic obstructive pulmonary disease
• The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion criteria

• asthma
• has received tracheotomy
• long term mechanical ventilation (which has been accepted for more than 21 days).
• severe pneumonia
• Patients who cannot use a patient with bronchial dilation
• there's a taboo on the use of a sedative.
• refusal to participate in the study
• 48 hours to pull out the tube

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

120 participants in 2 patient groups

Atomization inhalation

Active Comparator group

Description:

First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group

Treatment:

Drug: Salbutamol Aerosol

Without atomization inhalation

Active Comparator group

Description:

First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group

Treatment:

Drug: No drugs