Aizthromycin or Clarithromycin in H-pylori Eradication Regimen

Shahid Sadoughi University of Medical Sciences and Health Services

Status and phase: Completed; Phase 4

Conditions: Peptic Ulcer; Dyspepsia; H-pylori

Treatments: Drug: azithromycin; Drug: clarithmycin

Study type: Interventional

Funder types: Other

Identifiers

NCT01667692

ssu.hakimi-89027

Details and patient eligibility

About

The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Full description

Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available.

HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries.

There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs.

The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.

Enrollment: 78 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy

Exclusion criteria

• patients who got H-pylori eradication treatment previously
• patients who used study drugs during 3months before study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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78 participants in 2 patient groups

azithromycin

Experimental group

Description:

Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics. It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.

Treatment:

Drug: azithromycin

clarithromycin

Experimental group

Description:

Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.

Treatment:

Drug: clarithmycin