Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

University of Illinois at Urbana-Champaign

Status

Enrolling

Conditions

Alcoholism

Alcohol; Harmful Use

Alcohol Use Disorder (AUD)

Alcohol Intoxication

Binge Drinking

Alcohol Drinking

Treatments

Other: Control - non alcoholic beverage

Drug: Alcohol beverage

Study type

Interventional

Funder types

Other

Identifiers

NCT07125534

2R01AA025969-01

Details and patient eligibility

About

The study investigates the effects of alcohol consumption on social and individual behaviors using a within-subject design. Participants, aged 21-30, will attend two laboratory sessions approximately one week apart, participating as part of a dyad (pair). During one session, they will consume an alcoholic beverage, while in the other, they will receive a control beverage, with the order of conditions randomized. This design facilitates direct within-participant comparisons of behaviors and neural activity in intoxicated versus sober states.

To achieve these aims, the study employs EEG technology to explore intra-brain and inter-brain dynamics during social interactions. Additionally, validated self-report questionnaires will capture data on mood, social bonding, and other psychological variables. The findings are expected to enhance understanding of alcohol's role in social reward processes and contribute to developing evidence-based prevention and intervention strategies for alcohol use disorder.

Full description

Objective:

Alcohol's ability to enhance social bonding and modulate mood in social contexts has been identified as a key factor contributing to its reinforcing properties and risk for Alcohol Use Disorder (AUD). While prior research has demonstrated alcohol's role in enhancing social interactions, laboratory studies often fail to replicate the real-world context in which most alcohol consumption occurs-social settings with familiar companions. This discrepancy limits our understanding of the mechanisms through which alcohol exerts its effects in social contexts.

This study is the first to employ EEG hyperscanning methods to investigate the inter- and intra-brain mechanisms underlying alcohol's social rewards within dyadic interactions. Specifically, the study aims to characterize how alcohol modulates social bonding, emotional regulation, and neural synchrony during social interactions, and to identify the cognitive and affective processes driving alcohol's reinforcing properties. The findings are expected to deepen understanding of the role of alcohol in social dynamics and inform interventions for AUD.

Study Population:

The study will recruit 200 participants, aged 21-30, who self-identify as regular social drinkers and with no reported history of severe alcohol use disorder.

Design:

This within-subject laboratory study involves two experimental sessions spaced approximately one week apart. Each session includes participants interacting in dyads with a stranger, where they will consume either a moderate dose of alcohol (target BAC ~0.08%) or a non-alcoholic control beverage, with the order randomized between sessions. Participants will engage in structured and unstructured tasks during each session, allowing for the evaluation of behavioral, emotional, and neural outcomes in both intoxicated and sober states.

EEG Hyperscanning: Neural activity will be recorded simultaneously from both members of the dyad using EEG hyperscanning technology. This allows for the investigation of intra-brain processes (e.g., cognitive and emotional regulation) and inter-brain synchrony (e.g., neural alignment during social interactions).
Tasks and Measures: Participants will complete tasks designed to assess social bonding, emotional regulation, and cognitive processing. Tasks include structured paradigms (e.g., music perception tasks and flanker task) and naturalistic social interactions. These are complemented by self-report measures assessing mood, social closeness, and perceptions of the interaction.
Randomization and Counterbalancing: The order of alcohol versus control sessions will be randomized across participants to control for carryover effects.

Outcome Measures:

Neurophysiological Outcomes:

Intra and Inter Brain Coupling (IBC):
- Intra brain synchrony (within-subject): Coherence or phase-locking between brain regions within the same participant, compared across sober versus intoxicated states.
- Inter brain synchrony (between-subject): Synchronization metrics (e.g., inter subject PLV, inter subject correlation) between paired participants, assessed separately in sober and intoxicated conditions
Event Related Potentials (ERP):

• Amplitudes and latencies of task-related ERP components, specifically Feedback Related Negativity (FRN), measured both for the operating ("player") and observing ("observer") participant, with comparisons across sobriety conditions
Behavioral and Psychological Outcomes:

Self-reported mood and social bonding assessed pre- and post-interaction using validated measures such as the Inclusion of Other in Self Scale and the Biphasic Alcohol Effects Scale.

Observational coding of nonverbal behaviors (e.g., facial expressions, body language) during dyadic interactions.
Drinking Behavior:

Longitudinal self-reports of drinking patterns and alcohol-related outcomes.

Enrollment

200 estimated patients

Sex

All

Ages

21 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Between the ages of 21 and 30
Regularly consumes alcohol

Exclusion criteria

History of adverse reaction to the amount of beverage employed in the study
Have a history of major problems associated with alcohol
Take medications that could adversely interact with alcohol
Have medical conditions that contraindicate alcohol administration
Individuals with a history of skull fractures or who indicate discomfort with EEG procedures used
Female participant is pregnant or trying to become pregnant