Alcohol, Behavior, and Brain Imaging ((DARC))

The University of Chicago

Status and phase

Completed

Early Phase 1

Conditions

Central Nervous System Depressants

Physiological Effects of Drugs

Substance-Related Disorders

Ethanol

Drinking Behavior

Binge Drinking

Alcohol Drinking

Treatments

Other: Placebo

Drug: Ethanol

Study type

Interventional

Funder types

Other

Identifiers

NCT03930446

IRB16-0015

Details and patient eligibility

About

To evaluate the relationship of extraversion to both the acute subjective and behavioral effects of alcohol, and the neural reactivity to the anticipation of reward.

Enrollment

80 patients

Sex

All

Ages

21 to 29 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

21-29 years old
7-30 alcoholic drinks per week (as reported on PHQ or TLFB)
At least one binge episode (4 for females/5 for males) per month
No 'flushing' reaction to alcohol
Females must be on birth control or in the beginning of follicular phase (1-14 days after start of menstruation)
BMI 19-26
High school education or greater, fluent in English
No night shift work
No current or past year Axis I psychiatric disorder including drug/alcohol dependence
No current psychopharmacological treatment
No lifetime ADHD or prescription for ADHD medication
No abnormal EKG, cardiovascular illness, high blood pressure
No medical condition or pharmacological treatment for which alcohol is contraindicated
Not pregnant, lactating, or planning to become pregnant
Smoke <6 cigarettes per day
No previous participation in studies that have used the Stop Task (except IDAC) o Previous Stop Task studies: GOI, CAP, STEM, JAM, MACI, PAC, CAM