Alcohol Diet and Drug Use Preceding Alcoholic Hepatitis (ADDUP)

University Hospitals Birmingham NHS Foundation Trust (UHB)

Status: Unknown

Conditions: Hepatitis, Alcoholic

Treatments: Other: Interview

Study type: Observational

Funder types: Other

Identifiers

NCT02404636

RRK4357

Details and patient eligibility

About

ADDUP is an observational study of patients with alcoholic hepatitis. A structured interview is used to quantitatively estimate:

1. Alcohol use
2. Dietary intake
3. Drug use (legal and illegal)

in the weeks preceding onset of acute alcoholic hepatitis. After interview patients are followed up for 12 months with regard to response to therapy and survival.

The study is intended to explore potential precipitants of alcoholic hepatitis.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute alcoholic hepatitis
• aged over 18 years
• able to give informed consent

Exclusion criteria

• evidence of other acute or chronic liver disease
• episode of alcoholic hepatitis in 6 months before admission
• severe hepatic encephalopathy
• delirium

Trial design

50 participants in 2 patient groups

Alcoholic hepatitis

Description:

Individuals admitted to hospital with acute alcoholic hepatitis, defined as acute onset of jaundice in the context of recent hazardous alcohol use and the absence of other liver disease

Treatment:

Other: Interview

Hazardous alcohol use

Description:

Individuals admitted to hospital for any cause who drink hazardous quantities of alcohol but without evidence of alcoholic hepatitis or advanced liver disease

Treatment:

Other: Interview