ALI (Acute Lung Injury) /ARDS (Acute Respiratory Distress Syndrome) in Oncologic Pediatric Patients

Grupo de Apoio ao Adolescente e a Crianca com Cancer

Status: Completed

Conditions: Neoplasms; Acute Respiratory Distress Syndrome; Acute Lung Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01304654

0031/11 (Other Identifier)

UTI/IOP 02/11

Details and patient eligibility

About

Identify pediatric oncologic patients with ALI/ARDS at GRAACC (Grupo de Apoio ao Adolescente e a Criança com Câncer) /IOP's (Instituto de Oncologia Pediátrica) Pediatric Intensive Care Unit and evaluate the mechanical ventilation practice in these subjects for a 48mo period.

Full description

Evaluate adequate mechanical ventilation based on protective ventilation protocols for children available so far.

Evaluate and describe the subjects. Evaluate the necessity and outcome of rescue therapies (surfactant, prone position, corticosteroids, alveolar recruitment) Obtain data about ALI/ARDS' etiology, mortality rates and predictive factors related to the outcomes (PICU/ hospital discharge or death)

Enrollment: 29 patients

Sex: All

Ages: 29 days to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients admitted at the intensive care unit with diagnosis of acute lung injury or acute respiratory distress syndrome and submitted to mechanical ventilation for over 24h

Exclusion criteria

• mechanical ventilation less than 24h
• absence of ALI/ARDS criteria
• no neoplasm diagnosis

Trial design

29 participants in 1 patient group

ALI/ARDS oncologic patients

Description:

Consecutively admitted patients at GRAACC's PICU with malignancy diagnosis according to IDC-10, in a 24mo consecutive period, under mechanical ventilation for over 24h and with ALI/ARDS criteria, not younger than 29 days or older than 17 years 11 months