Almond Supplementation on Mild to Moderate Acne

Integrative Skin Science and Research

Status: Enrolling

Conditions: Acne Vulgaris

Treatments: Other: Food: non-nut snack; Other: Food: whole almonds

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05269641

AlmondAcne_01

Details and patient eligibility

About

This study will assess the effect of almond supplementation on acne and on gut health.

Enrollment: 60 estimated patients

Sex: All

Ages: 15 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects 15 years of age until 45 years of age.
• The presence of mild to moderate acne based on investigator global assessment.
• Individuals who have remained stable on their topical or oral acne regimen for at least 4 weeks, except if the medication is a noted exclusion.

Exclusion criteria

• The presence of severe acne as noted by the investigator global assessment.
• Those with a nut allergy.
• Those who are unwilling to discontinue oral probiotic-based supplementation to meet the washout criteria prior to enrolling.
• Those who are unwilling to discontinue topical antibiotics and topical benzoyl peroxide to meet the washout criteria prior to enrolling.
• Individuals who are unwilling to discontinue vitamin E containing supplements during the washout and intervention.
• Individuals who have been on an oral antibiotic for acne within the previous 1 month.
• Individuals who are pregnant or breastfeeding.
• Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
• Oral supplementation that has nuts in it.
• Use of isotretinoin within the three months prior to joining the study.
• Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 2 patient groups, including a placebo group

Almonds

Experimental group

Description:

Daily consumption of almonds.

Treatment:

Other: Food: whole almonds

Control Snack

Placebo Comparator group

Description:

Daily non-nut snack will be consumed.

Treatment:

Other: Food: non-nut snack