Aloe Vera in Chronic Periodontitis With Type 2 Diabetes Mellitus

Government Dental College and Research Institute, Bangalore

Status and phase: Completed; Phase 3; Phase 2

Conditions: Chronic Periodontitis

Treatments: Drug: aloe vera; Drug: placebo gel

Study type: Interventional

Funder types: Other

Identifiers

NCT02386020

GDCRI/ACM/PG/PhD/10E/2013-14

Details and patient eligibility

About

The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM).

Full description

BACKGROUND: Advances in the field of alternative medicine have promoted widespread use of herbal agents, like Aloe vera (AV), for both medical and dental therapy. AV has anti-inflammatory, antioxidant, antimicrobial, hypoglycaemic, healing promoting and immune boosting properties. The present study is designed to investigate the effectiveness of AV gel local drug delivery as an adjunct to scaling and root planing (SRP) in the treatment of subjects with chronic periodontitis (CP) and type 2 diabetes mellitus (DM).

MATERIAL AND METHODS: A total of 60 subjects with probing depth (PD) ≥5mm and clinical attachment level (CAL) ≥3mm were randomly divided into two groups. Group 1 was treated with SRP + placebo gel local drug delivery (LDD) and Group 2 with SRP + AV gel LDD. Clinical parameters including full mouth plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD) and clinical attachment level (CAL) were recorded first at baseline and then at intervals of 3 months and 6 months.

Enrollment: 60 patients

Sex: All

Ages: 25 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Well-controlled type 2 DM
• Chronic periodontitis with moderate to deep pockets [probing depth (PD) ≥5mm and clinical attachment loss (CAL) ≥3mm]
• No history of antibiotic or periodontal therapy in the preceding 6 months.

Exclusion criteria

• Any known disease/condition or on any medication that can affect the periodontal status
• Known or suspected allergy to herbal medications
• Systemic antimicrobial therapy
• Aggressive periodontitis
• Smokers
• Alcoholics
• Immunocompromised patients
• Pregnant or lactating females

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

After SRP, placebo gel was delivered subgingivally into periodontal pockets.

Treatment:

Drug: placebo gel

Aloe vera

Active Comparator group

Description:

After SRP, aloe vera gel was delivered subgingivally into periodontal pockets.

Treatment:

Drug: aloe vera