Aloe Vera in Irritable Bowel Syndrome

Sahlgrenska University Hospital

Status: Completed

Conditions: Irritable Bowel Syndrome

Treatments: Dietary Supplement: Placebo control; Dietary Supplement: Aloe vera effervescent tablet (AVH200)

Study type: Interventional

Funder types: Other

Identifiers

NCT01400048

Aloe Vera AVH200

Details and patient eligibility

About

The purpose of the present study is to study the effect of aloe vera in the treatment of IBS patients in a randomized, double-blind placebo controlled study.

Full description

There is limited knowledge of the IBS pathophysiology, absence of biological markers and therefore few effective treatment options. IBS therefore contributes to difficulties in the management of the patients. Aloe vera has a long association with herbal medicine, from the Ebers Papyrus from 16th century BCE. It is alleged to be effective in treatment of wounds, to improve blood glucose levels in diabetics, and it may reduce symptoms and inflammation in patients with ulcerative colitis. Evidence of the effects of aloe vera in the treatment of IBS, is however limited and contradictory.

Enrollment: 173 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• IBS according to the Rome III criteria
• Adults

Exclusion criteria

• other GI disorders
• other medical conditions
• were pregnancy or breast-feeding
• food allergy or intolerance to other than lactose
• ongoing intake of aloe vera products

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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173 participants in 2 patient groups, including a placebo group

Aloe vera effervescent tablet (AVH200)

Active Comparator group

Treatment:

Dietary Supplement: Aloe vera effervescent tablet (AVH200)

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo control