ALPPS (Liver Partition and Portal Vein Ligation) for Two-stage Hepatectomy for Colorectal Liver Metastasis

Centre Hospitalier Universitaire, Amiens

Status and phase: Terminated; Phase 3

Conditions: Colorectal Cancer

Treatments: Procedure: two stage hepatectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT01842971

A41707-36 (Other Identifier)

PI2012_843_0028

Details and patient eligibility

About

The aim of this study is evaluate the feasibility of early two-stage hepatectomy in patients with liver metastasis from colorectal cancer.

Full description

In France, each year around 36,000 new cases of colorectal cancers are registered responsible in 16,000 deaths because of liver metastasis.

In case of bilobar metastasis, classic two-stage hepatectomy with portal embolization could be performed.

An alternative to the classic surgery, early two stage hepatectomy, could be proposed to simplify the patient's management and to improve the resectability.

Enrollment: 3 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• potentially resectable liver metastasis from colorectal cancer
• portal embolisation required
• older than 18 years old

Exclusion criteria

• synchronous surgery on the colon or the rectum
• extra hepatic metastasis
• history of hepatectomy
• pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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3 participants in 1 patient group

two stage hepatectomy

Experimental group

Description:

the two stage hepatectomy is defined as a two step procedure: first step: hepatotomy with ligature of the right branch of the portal vein second step (one week after the first step): right hepatectomy

Treatment:

Procedure: two stage hepatectomy