Alteration of Thrombelastography and Coagulation Function in Patients Undergoing Total Knee Arthroplasty With Intra-articular Tranexamic Acid Administration

Shanghai Jiao Tong University

Status: Not yet enrolling

Conditions: Arthropathy of Knee

Treatments: Drug: Tranexamic acid

Study type: Observational

Funder types: Other

Identifiers

NCT05490160

IIT-2022-0059

Details and patient eligibility

About

The main aim and scope of this study is making comparison about the thrombelastography and coagulation function in patients before and after the total knee arthroplasty with intra-articular tranexamic acid administration. The results may identify the influence of the intra-articular tranexamic acid administration on the relative coagulability monitoring.

Enrollment: 54 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients received primary total knee arthroplasty;
• Normal pre-operative coagulation function;
• Complete surgery document, transfusion document and relative blood test.

Exclusion criteria

• The patients received complicated total knee arthroplasty;
• Abnormal pre-operative coagulation function caused by some diseases such as hepatic inadequacy, thrombocytopenia et al.
• Incomplete documents.

Trial design

54 participants in 2 patient groups

Tranexamic acid group

Description:

During the total knee arthroplasty, the patients received a 2-g retrograde injection of tranexamic acid through the drain after closure, with subsequent clamping of the drain for 6 hours.

Treatment:

Drug: Tranexamic acid

Non-tranexamic acid group

Description:

During the total knee arthroplasty, the patients did not receive tranexamic acid administration.