Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

Turku University Hospital (TYKS)

Status: Completed

Conditions: Pelvic Organ Prolapse

Study type: Observational

Funder types: Other

Identifiers

NCT01749696

33/180/2009

Details and patient eligibility

About

The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

Full description

The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.

The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Enrollment: 78 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• surgery for pelvic organ prolapse
• hysterectomy due to other benign reasons than pelvic organ prolapse

Exclusion criteria

• surgery due to malignancy

Trial design

78 participants in 2 patient groups

Patients with pelvic organ prolapse

Description:

Patients, who were operated on because of pelvic organ prolapse.

Patients without pelvic organ prolapse

Description:

Patients, who had hysterectomy due to other reasons than pelvic organ prolapse.