Alterations in Muscle After Total Knee Arthroplasty

University of Colorado Denver (CU Denver)

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Procedure: Neuromuscular electrical stimulation (NMES); Behavioral: Standard Rehabilitation Protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT02281877

14-0905

Details and patient eligibility

About

The overall goals of this work are: 1) to elucidate alterations in gene expression and downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved maintenance of muscle strength with Neuromuscular Electrical Stimulation (NMES) utilization. Furthermore, this investigation seeks to expand previous findings regarding attenuation of strength and functional performance deficits with NMES application to better understand how altered gene expression influences muscle function.

Enrollment: 20 estimated patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 50 to 75 years of age
• Scheduled for unilateral TKA at University of Colorado Hospital
• Diagnosed with osteoarthritis
• Cognitive status that allows patients to consistently comprehend and repeat back directions regarding the details of the study

Exclusion criteria

• Neurological, vascular or cardiac problems that significantly limit function
• BMI > 35
• Testosterone supplementation
• Pregnancy
• Anticoagulant therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Neuromuscular Electrical Stimulation

Experimental group

Description:

Neuromuscular Electrical Stimulation (NMES) 48 hours after TKA, 5x/week, 2x/day, for 45 minutes/session. Standard Rehabilitation Protocol

Treatment:

Behavioral: Standard Rehabilitation Protocol

Procedure: Neuromuscular electrical stimulation (NMES)

Control

Active Comparator group

Description:

Standard Rehabilitation Protocol

Treatment:

Behavioral: Standard Rehabilitation Protocol