Alterations in Postprandial Glucose and Lipid Metabolism in Patients With Obstructive Sleep Apnea

Kyoto University, Graduate School of Medicine

Status

Completed

Conditions

Obstructive Sleep Apnea

Treatments

Device: CPAP treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT00942110

C-311

Details and patient eligibility

About

The purpose of this study is to examine postprandial glucose and lipid metabolism in patients with obstructive sleep apnea.

Full description

Obstructive sleep apnea (OSA) is an increasingly prevalent condition that is characterized by repetitive upper airway obstructions. OSA has been independently associated with insulin resistance, suggesting that OSA may contribute to the development of type 2 diabetes and the metabolic syndrome. Recently, postprandial glucose and lipid have been reported as excellent predictors for mortality and cardiovascular risk. However, the association between postprandial glucose, lipid metabolism and OSA are not clear. In addition, humoral factors such as ghrelin and leptin are associated with obesity and OSA, but postprandial changes of which in patients with OSA are not well known. The aim of present study is to examine postprandial glucose and lipid metabolism, humoral factors in OSA before and after 3 months of continuous positive airway pressure (CPAP) treatment.

Enrollment

58 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital.
Subjects diagnosed with OSA (apnea hypopnea index >=5/hour) by overnight polysomnography.

Exclusion criteria