Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma

Tokat Gaziosmanpasa University

Status: Completed

Conditions: Occlusal Trauma; Chronic Periodontitis

Study type: Observational

Funder types: Other

Identifiers

NCT03621891

balciyuce84

Details and patient eligibility

About

Present study suggests that excessive occlusal forces did not cause a significant change in hypoxia and vascular markers, however a slight alteration in subgingival microbiota was observed.

Full description

Occlusal trauma is defined as tissue destruction and/or injury resulting in tissue changes in the periodontium as a consequence of excessive occlusal forces or hyper-occlusion. Previous studies suggested accelerated periodontal destruction around teeth with occlusal trauma and increased mobility, however, the evidence is lacking. Recent animal studies found that occlusal trauma increased osteoclastic activity and alveolar bone loss. One possible mechanism suggested for the progression of periodontal destruction with occlusal trauma is that tooth mobility creates a subgingival environment conducive to overgrowth by periodontal pathogens. However, the association of occlusal trauma and subgingival microbiota was not evaluated in previous studies. Therefore, present study aimed to evaluate subgingival dental plaque components and compare with healthy individuals and periodontitis patients without occlusal trauma.

Enrollment: 80 patients

Sex: All

Ages: 29 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Systemical health
• No drug use
• No pregnancy or lactation For group 3 and 4;
• Bruxism at least for 2 years
• Occlusal trauma
• Existence of at least 20 functioning teeth

Exclusion criteria

• Smoking
• Pregnancy/lactation
• Systemical disease
• Drug use
• Absence of at least 20 functioning teeth

Trial design

80 participants in 4 patient groups

healthy individuals

Description:

Orally and systemically healthy individuals who has no hypo-functional teeth, hyper-occlusion or occlusal trauma

periodontitis patients

Description:

Systemically healthy individuals who has chronic periodontitis but no hypo-functional teeth, hyper-occlusion or occlusal trauma

healthy-occlusal trauma

Description:

Orally and systemically healthy individuals who has occlusal trauma caused by bruxism

periodontitis-occlusal trauma

Description:

Systemically healthy individuals who has both chronic periodontitis and occlusal trauma caused by bruxism