Altered Faecal Protease Activity in Irritable Bowel Syndrome Patients in China

Health Science Center of Xi'an Jiaotong University

Status: Unknown

Conditions: Irritable Bowel Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01060527

xi'an JTU091202

Details and patient eligibility

About

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder haracterised by abdominal pain or discomfort associated with altered bowel habits,while the mechanism is still not understood.Recent advances have conceptualized the faecal supernatants of diarrhoea-predominant IBS have a substantially higher serine protease activity, while in china,almost no studies have reported about protease activity in IBS.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients fulfilling the Rome III criteria for IBS participated in the study -

Exclusion criteria

• Organic gastrointestinal disorders were excluded by detailed blood and stool analyses, serological assays and colonoscopy.

Trial design

60 participants in 3 patient groups

IBS-D

IBS-C

Controll