Altered Hemorology in Adolescent Idıopathic Scoliosis (AHIAIS)

Fatih Sultan Mehmet Training and Research Hospital

Status: Completed

Conditions: Idiopathic Adolescent Scoliosis

Study type: Observational

Funder types: Other

Identifiers

NCT07102862

SBU-2025 (Other Identifier)

AHIAIS-2025

Details and patient eligibility

About

This study aims to investigate potential alterations in hemorheological parameters in adolescents with idiopathic scoliosis (AIS) compared to healthy controls. A total of 30 AIS patients and 30 age- and sex-matched healthy individuals will be evaluated through clinical, radiological, and laboratory assessments. Hematocrit, plasma and whole blood viscosity, erythrocyte deformability, and aggregation will be measured. The goal is to determine whether structural spinal deformities in AIS are associated with changes in microcirculatory blood flow properties.

Full description

Adolescent idiopathic scoliosis (AIS) is the most common type of scoliosis in children and adolescents. Although extensively studied from orthopedic and biomechanical perspectives, its potential systemic effects remain poorly understood. This study is designed to investigate whether AIS is associated with alterations in blood rheology-specifically, changes in viscosity, erythrocyte deformability, and aggregation-which may reflect underlying microcirculatory dysfunction.

Hemorheology refers to the study of blood flow and its mechanical properties. In this study, key hemorheological parameters-including hematocrit (Hct), whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte deformability (ED), and erythrocyte aggregation (EA)-will be assessed in AIS patients and healthy controls. A total of 30 AIS patients and 30 age- and sex-matched healthy participants will be enrolled.

Blood samples will be collected for rheological analysis, and measurements will be performed using a rotational cone-plate viscometer and a laser-optical erythrocyte analyzer under standardized shear conditions. Clinical and radiological data, such as Cobb angle, vertebral rotation, and sagittal alignment, will also be collected. Statistical comparisons between groups and correlation analyses will be conducted to evaluate the relationships between hemorheological variables and scoliosis severity or type.

This study will provide the first controlled assessment of hemorheological behavior in adolescents with idiopathic scoliosis. Results may offer novel insights into whether spinal deformity has systemic circulatory implications and may help identify early markers of microvascular dysfunction associated with AIS.

Enrollment: 60 patients

Sex: All

Ages: 10 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Presence of structural scoliosis with a Cobb angle greater than 10°
• Age between 10 and 18 years

Exclusion criteria

• Other types of scoliosis, such as syndromic conditions, congenital vertebral deformities, and neuromuscular scoliosis
• Presence of any diseases or conditions that may affect hemorheology, such as cardiovascular, respiratory, and hematologic diseases
• Obesity (Body mass index [BMI] > 30)
• Being treated surgically for scoliosis

Trial design

60 participants in 2 patient groups

Patients

Description:

10-18 years old AIS patients

Control Healthy Subjects

Description:

Sex and aged match healthy subjecyts