Alternative to Two-Stage Hepatectomy

University of Milan

Status: Completed

Conditions: Liver Metastases; Colorectal Cancer

Treatments: Procedure: One-stage ultrasound guided hepatectomy

Study type: Observational

Funder types: Other

Identifiers

NCT00587756

MTX-CRC-1STAGE

MTX-1STAGE

Details and patient eligibility

About

Two-stage hepatectomy with or without portal vein embolization allows to treat multiple bilobar metastases expanding surgical indications for these patients. However, it has some related drawbacks: two operations are needed, and some patients do not complete the treatment strategy for disease progression. Using experience gained from our ultrasound guided resection policy we explored the safety and effectiveness of one-stage surgical procedures in patients otherwise recommended for the two-stage approach.

Enrollment: 19 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients presenting with resectable colorectal cancer liver metastases (CLM)
2. 4 or more lesions
3. Bilobar involvement of the liver
4. Contact or close adjacency (less than 0.5 cm) of at least one CLM with major intrahepatic vascular structures (1st or 2nd order portal branches and/or hepatic vein at caval confluence).

Exclusion criteria

1. Patients with 3 or less resectable CLM
2. Patients with 4 or more resectable CLM but nor bilobar
3. Patients with 4 or more bilobar resectable CLM without any lesion presenting condition of point 4 of the inclusion criteria

Trial design

19 participants in 1 patient group

1

Description:

Prospective cohort of consecutive patients who undergo surgery for colorectal cancer liver metastases

Treatment:

Procedure: One-stage ultrasound guided hepatectomy