Alveolar Macrophage Proteomics in HIV-associated Emphysema (HIVE)

Philip Diaz

Status: Completed

Conditions: HIV; Emphysema; HIV Infections

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00823927

2005H0197

Details and patient eligibility

About

This study is being done to examine lung function changes in individuals with HIV infection and to understand why individuals with HIV have increased risk of lung damage from cigarette smoking.

Full description

To delineate the natural history of HIV associated emphysema in the HAART era. To compare the alveolar macrophage proteomes from HIV-seropositive smokers with emphysema to the alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers.

To establish whether coinfection with HIV and Hepatitis C results in accelerated lung disease manifested by decrements in forced expiratory volume and carbon monoxide diffusing capacity.

Enrollment: 365 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically stable HIV-seropositive (and HIV-seronegative) individuals
• Ages 18 years and older
• Female subjects on no oral contraception with a negative pregnancy test
• Subjects capable of giving written consent

Exclusion criteria

• Known medical illness that would preclude bronchoscopy/BAL (e.g. unstable angina, new cardiac arrhythmia). This only pertains to subjects involved in the bronchoscopy phase of the study.
• Pregnant females
• Prisoners

Trial design

365 participants in 2 patient groups

1

Description:

Alveolar macrophage proteomes from HIV-seropositive smokers with emphysema

2

Description:

Alveolar macrophages proteomes of both HIV+ smokers without emphysema and HIV- smokers.