Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction

Cairo University (CU)

Status: Not yet enrolling

Conditions: Alveolar Ridge Preservation

Treatments: Procedure: biologically oriented alveolar ridge preservation; Procedure: xenogenic bone graft in entire (apico-coronal) extension

Study type: Interventional

Funder types: Other

Identifiers

NCT05553548

8722

Details and patient eligibility

About

After tooth extraction, the alveolar process undergoes substantial horizontal and vertical resorption specifically in non-molar sites, where horizontal, vertical mid- facial, and mid-lingual ridge reduction could occur . These dimensional changes are clinically relevant, as they may affect dental implant placement and compromise soft tissue aesthetics.

Alveolar ridge preservation (ARP) is based on the application of a bone replacement graft into the extraction socket & collagen membrane/plug. Recent systematic reviews have shown that ARP may limit bone resorption to about 50% of what is normally observed in case of unassisted healing . This finding indicates that ARP is effective; but at the same time, it underlines the potential for improvement.

Full description

In ARP procedures based on socket grafting, the use of a bone replacement graft would prevent up to a 30% of volume reduction in the coronal third. Whereas it has limited effect in the remaining middle-apical thirds . Since grafting of the alveolus often results in the persistence of residual graft particles embedded into the newly formed bone with a delay in the rate of bone deposition and mineralization the need to extend the grafting procedure apical to the coronal third of the socket seems questionable. Based on these considerations, a novel, simplified technique, namely, the Biologically-oriented Alveolar Ridge Preservation (BARP) for ARP that restricts socket grafting to the coronal portion of the socket was presented .

Enrollment: 36 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults 18 years old or more.
• Patients with good oral hygiene, defined as a full-mouth plaque score ≤25% (O'Leary et al., 1972).
• Patients who need alveolar ridge preservation after tooth extraction at one or two sites in the aesthetic zone (incisor, cuspid, or premolar area in the maxilla or mandible) with >50% buccal bone present following tooth extraction (Eeckhout et al., 2022) .
• One or two neighboring teeth.
• Compliant patients who will sign an informed consent and agree to the follow up period.

Exclusion criteria

• • Uncontrolled systemic disease

  • Past or current smoking
  • Untreated or unstable periodontitis
  • Untreated caries lesions.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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36 participants in 2 patient groups

biologically oriented alveolar ridge preservation (BARP) group

Experimental group

Description:

for alveolar ridge preservation using demineralized bovine bone graft layer in the most coronal part of the extracted tooth socket

Treatment:

Procedure: biologically oriented alveolar ridge preservation

bone graft (entire apico-coronal extension)

Active Comparator group

Description:

alveolar ridge preservation using demineralized bovine bone graft on the entire apico-coronal extension.

Treatment:

Procedure: xenogenic bone graft in entire (apico-coronal) extension