Alveolar Ridge Preservation Following Tooth Extraction Using Advanced Platelet Rich Fibrin (A-PRF) Versus Platelet Rich Fibrin (PRF)

Cairo University (CU)

Status: Unknown

Conditions: Alveolar Bone Resorption

Treatments: Procedure: Advanced platelet rich fibrin (A-PRF); Procedure: blood clot; Procedure: Platelet rich fibrin (PRF)

Study type: Interventional

Funder types: Other

Identifiers

NCT04434703

6-3-1

Details and patient eligibility

About

the aim of this study is clinically and radiographically evaluate the use of advance platelet rich fibrin (A-PRF) versus platelet rich fibrin (PRF) in preservation of alveolar ridge following tooth extraction

Full description

systemically healthy patients who have at least one non-restorable tooth in the upper inter-bicuspid region and are not seeking immediate or early implant treatment will be allocated in this study after performing nonsurgical periodontal therapy and preoperative periapical therapy to evaluate and improve the condition of the periodontal tissues.

Anesthesia will be given then flapless atraumatic extraction using periotomes followed by forceps after luxation. For all groups, the socket will be debrided using curette then

• group A, the socket will be filled with A.PRF
• group B the socket will be filled with PRF.
• group C no bio-additive will be added.
• Criss cross horizontal mattress suture will be applied to close the extraction wound.

PRF and A-PRF preparation :

10 ml of blood will be drawn from each patient by vein puncture of the antecubital vein.

• Plateletr ich fibrin (PRF) is 3000 rpm and 10 minutes without addition of anticoagulant
• Advanced platelet rich fibrin (A-PRF) is 1300 rpm and 8 minutes.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with at least one non restorable tooth in upper inter-bicuspid region.
• Stable periodontal condition with no acute periapical infection.
• Systematically healthy conditions.
• Cooperative patients.
• Intact buccal plate of bone.

Exclusion criteria

• Smokers.
• Patients seeking immediate or early implants.
• Pregnant females.
• Bone diseases.
• Drugs and diseases that may affect platelet count or function.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups, including a placebo group

Platelet rich fibrin (PRF)

Active Comparator group

Description:

Platelet rich fibrin is the secoond generation of platelet concentrates which is an autogenous biomaterial that is prepared from the patient's own blood

Treatment:

Procedure: Platelet rich fibrin (PRF)

Advanced platelet rich fibrin (A-PRF)

Experimental group

Description:

Advanced platelet rich fibrin is the last modification of PRF which is expected to contain a relatively greater number of white blood cellsand growth factors

Treatment:

Procedure: Advanced platelet rich fibrin (A-PRF)

blood clot

Placebo Comparator group

Description:

normal healing of the wound without adding any biomaterial

Treatment:

Procedure: blood clot