Alveolar Ridge Preservation Using Different Bone Substitutes

Ain Shams University

Status and phase: Completed; Phase 3

Conditions: Alveolar Ridge Enlargement

Treatments: Drug: Allograft; Drug: Alloplast; Drug: Toothgraft

Study type: Interventional

Funder types: Other

Identifiers

NCT05812872

FDASU-RecIR092210

Details and patient eligibility

About

The primary objective of this study was to compare the efficacy of using allograft, autogenous tooth graft, and beta-tricalcium phosphate for alveolar ridge preservation (ARP) by examining the alveolar ridge height and width at baseline and 3 months after the ARP both clinically and radiographically. The secondary objective was to evaluate the quality of the newly formed bone using histomorphometric analysis.

Full description

This randomized controlled clinical trial included thirty patients. ARP was performed using either Allograft (Allograft group n=10), Tooth graft (Toothgraft group n=10), and beta tri-calcium- phosphate (beta tri-calcium group n=10). Changes in alveolar ridge dimensions were evaluated clinically and radiographically using cone beam computed tomography at baseline and 3 months. Core bone biopsy samples were obtained 3 months post-extraction during implant placement for histomorphometric analysis.

Enrollment: 30 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. seeking implant-based restorations after tooth extraction.
2. exhibited no evidence of any significant medical history, measured using Burket's Oral medicine health history questionnaire.
3. exhibited Type I and II sockets

Exclusion criteria

1. nonsmokers.
2. Pregnant and breast-feeding females
3. patients with known contraindications to dental implant surgery (e.g., increased bleeding tendency, history of treatments such as radiotherapy,

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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30 participants in 3 patient groups

Alveolar ridge preservationwith tooth graft

Active Comparator group

Description:

tooth graft

Treatment:

Drug: Toothgraft

Alveolar ridge preservation with allograft

Active Comparator group

Description:

Allograft

Treatment:

Drug: Allograft

Alveolar ridge preservation with alloplast

Active Comparator group

Description:

Beta Tri-Calcium phosphate

Treatment:

Drug: Alloplast