Alveolar Ridge Preservation With Cortico-cancellous Porcine Bone

University of Pisa

Status: Active, not recruiting

Conditions: Tooth Extraction Site Healing; Implant Therapy; Alveolar Ridge Preservation

Treatments: Procedure: tooth extraction with alveolar ridge preservation; Procedure: Implant placement

Study type: Observational

Funder types: Other

Identifiers

NCT06970184

BONEISTO_ARP

Details and patient eligibility

About

Observational, prospective study conducted on patients requiring tooth extractions followed by ARP and subsequent implant placement.

Full description

The primary aim of this study is to compare the histomorphometric characteristics of two different formulations of CCPB used for ARP, and the secondary aim is to evaluate and compare clinical and aesthetic outcomes of dental implants placed in augmented sites.

Patients requiring the extraction of an hopeless tooth followed by ARP and subsequent implant placement are considered potentially eligible for the study.

At T0, Tooth extractions are performed trying to reduce the surgical trauma as possible. ARP is performed with 2 different combinations of a cortico-cancellous porcine bone with a thermogel (50:50 ratio, hand-mixed or 80:20 ratio, pre-mixed).

After 4 months of healing, patients undergo a radiographic examination before implant placement.

A T1, Implant site preparation is carried out using a trephine bur (to remove a core biopsy of the bone) followed by conventional osteotomy drills, and bone-level implants are placed. Bone samples are analyzed to evaluate new bone formation, presence of residual graft particles and marrow spaces.

Three months after placement, all implants are rehabilitated with screw-retained prosthetic crowns (T2).

Follow up is scheduled 1 year after prosthetic loading (T3).

Enrollment: 22 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 yo
• Needing tooth extraction followed by ARP and implant-prosthetic rehabilitation

Exclusion criteria

• uncontrolled systemic diseases
• uncontrolled periodontitis
• undergoing previous or actual treatment with medications/radiations potentially impairing hard and soft tissues healing
• women during pregnancy or breastfeeding

Trial design

22 participants in 2 patient groups

ARP 50:50

Description:

Tooth extraction + ARP with collagenated porcine bone hand-mixed (ratio 50:50) with a thermogel

Treatment:

Procedure: Implant placement

Procedure: tooth extraction with alveolar ridge preservation

ARP 80:20

Description:

Tooth extraction + ARP with collagenated porcine bone pre-mixed (ratio 80:20) with a thermogel

Treatment:

Procedure: Implant placement

Procedure: tooth extraction with alveolar ridge preservation