Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma

National Cancer Institute (NCI)

Status and phase: Completed; Phase 1

Conditions: Stage IV Small Lymphocytic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage IV Marginal Zone Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Stage I Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Stage I Small Lymphocytic Lymphoma; Recurrent Marginal Zone Lymphoma; B-cell Chronic Lymphocytic Leukemia; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Grade 1 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Refractory Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage I Grade 1 Follicular Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia; Recurrent Small Lymphocytic Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Stage II Chronic Lymphocytic Leukemia; Nodal Marginal Zone B-cell Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage III Marginal Zone Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Refractory Hairy Cell Leukemia; Untreated Hairy Cell Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage I Mantle Cell Lymphoma

Treatments: Drug: alvocidib; Other: pharmacological study; Drug: fludarabine phosphate; Biological: rituximab

Study type: Interventional

Funder types: NIH

Identifiers

NCT00058227

OSU 0211

OSU-0211

OSU-02H0281

NCI-2012-01434

CDR0000287196

NCI-5745

U01CA076576 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This phase I trial studies the side effects, best way to give, and the best dose of alvocidib when given together with fludarabine phosphate and rituximab in treating patients with previously untreated or relapsed lymphoproliferative disorders or mantle cell lymphoma. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Drugs used in chemotherapy such as alvocidib and fludarabine use different ways to stop cancer cells from dividing so they stop growing or die. Combining monoclonal antibody therapy with chemotherapy may kill more cancer cells.

Full description

PRIMARY OBJECTIVES:

I. To determine a safe and tolerated dose of flavopiridol (alvocidib) in combination with standard dose rituximab and fludarabine (fludarabine phosphate) in patients with indolent B-cell lymphoproliferative disorders and mantle cell lymphoma.

II. To assess the toxicity of the combination regimen of flavopiridol, rituximab and fludarabine in patients with indolent B-cell lymphoproliferative disorders and mantle cell lymphoma.

III. To determine the safety, toxicity and efficacy of administering flavopiridol as a 30-minute bolus followed by 4-hour infusion, in combination with rituximab and fludarabine in patients with indolent B-cell lymphoproliferative disorders and mantle cell lymphoma.

SECONDARY OBJECTIVES:

I. To determine pharmacokinetics of the combination regimen of flavopiridol, rituximab and fludarabine in patients with indolent B-cell lymphoproliferative disorders and mantle cell lymphoma.

II. To determine pharmacodynamics of the combination regimen of flavopiridol, rituximab and fludarabine in patients with indolent B-cell lymphoproliferative disorders and mantle cell lymphoma.

OUTLINE: This is a dose-escalation study of alvocidib.

Patients receive fludarabine phosphate intravenously (IV) over 15-30 minutes on days 1-5 and rituximab IV over 3-4 hours on day 1. Alvocidib is administered IV over 60 minutes on day 1 in cohort 1; on days 1 and 2 in cohort 2; and on days 1, 2, and 3 in cohort 3. In cohorts 4 and 5, patients receive fludarabine phosphate and rituximab as above and alvocidib IV over 30 minutes and then IV over 4 hours on day 1 of courses 2-6. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.

PROJECTED ACCRUAL: A total of 37 patients will be accrued for this study.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Histologically confirmed mantle cell lymphoma OR indolent B-cell lymphoproliferative disorders of any of the following types:

  • Chronic lymphocytic leukemia
  • Small lymphocytic lymphoma
  • Follicular center cell non-Hodgkin's lymphoma (grade I or II)
  • Marginal zone lymphoma
  • Waldenstrom's macroglobulinemia
  • Hairy cell leukemia

• Previously untreated or relapsed/refractory disease

• No evidence of histological transformation to an intermediate-grade or aggressive lymphoma

• CD20 positive by immunoperoxidase or flow cytometry

• Evaluable disease with presence of 1 of the following criteria:

  • Absolute lymphocyte count greater than 5,000/mm^3
  • At least 1 measurable node greater than 2 cm by computed tomography (CT) scan OR measurable disease in a lymphoid structure (spleen)
  • Bone marrow involvement (greater than 20% of marrow cellularity)

• Performance status - Eastern Cooperative Oncology Group (ECOG) 0-2

• See Disease Characteristics

• Absolute neutrophil count at least 1,500/mm^3

• Platelet count at least 100,000/mm^3

• Hemoglobin at least 9.0 g/dL

• Bilirubin no greater than 2 times normal

• Aspartate aminotransferase (AST) no greater than 2 times normal

• Creatinine no greater than 2.0 mg/dL

• Creatinine clearance at least 50 mL/min

• No renal dysfunction that would impair tolerance or compliance with study therapy

• No cardiac dysfunction that would impair tolerance or compliance with study therapy

• No pulmonary dysfunction that would impair tolerance or compliance with study therapy

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No chronic gastrointestinal disease (e.g., Crohn's disease, ulcerative colitis, short gut syndrome) that would impair tolerability of compliance with therapy

• No neurological or psychiatric dysfunction that would impair tolerability of or compliance with study therapy

• At least 6 weeks since prior nitrosourea or mitomycin

• No more than 6 prior courses of fludarabine

• No concurrent corticosteroids as antiemetics

• At least 4 weeks since prior therapy for disease

• No more than 3 prior treatments for disease (not including steroids alone)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 1 patient group

Treatment (alvocidib, fludarabine phosphate, rituximab)

Experimental group

Description:

Patients receive fludarabine phosphate IV over 15-30 minutes on days 1-5 and rituximab IV over 3-4 hours on day 1. Alvocidib is administered IV over 60 minutes on day 1 in cohort 1; on days 1 and 2 in cohort 2; and on days 1, 2, and 3 in cohort 3. In cohorts 4 and 5, patients receive fludarabine phosphate and rituximab as above and alvocidib IV over 30 minutes and then IV over 4 hours on day 1 of courses 2-6. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.

Treatment:

Biological: rituximab

Drug: fludarabine phosphate

Other: pharmacological study

Drug: alvocidib