Alzheimer and Sleep

University Hospital, Clermont-Ferrand

Status and phase: Completed; Phase 1

Conditions: Alzheimer's Disease

Treatments: Drug: Galantamine and Donepezil

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00750529

CHU-0038

Details and patient eligibility

About

The aim of the study is the analysis of two inhibitors of Ach-E: galantamine and donépézil in over 65 years' old patients suffering from Alzheimer disease (MMSE between 20 and 26) without Alzheimer's medication.

Full description

Feasibility study, open, randomized, controlled, cross-over study in 65 years old patients.

Enrollment: 15 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 65 and over years old
• Patients suffering from Alzheimer disease
• Patient living with someone at home
• Written consent given

Exclusion criteria

• Galantamine or Donepezil hypersensibility
• Patient living alone and in a medicalized structure
• Concomitant medication
• Chronical diseases

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Galantamine

Experimental group

Treatment:

Drug: Galantamine and Donepezil