Alzheimer's Disease Core Center (ADCC)

University of Arizona

Status

Enrolling

Conditions

Alzheimer's Disease

Age-Related Memory Disorders

Mild Cognitive Impairment

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT01421420

P30AG019610 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The main objective of this research project is to provide a comprehensive clinical database of patients with Alzheimer's disease (AD) and other forms of dementia, individuals with mild cognitive impairment (MCI), and age-matched normal controls. The study will also attempt to identify cognitively normal individuals at genetically defined risk for Alzheimer's disease through genetic screening.

All participants are seen annually. Autopsies to establish diagnoses in patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Full description

All participants are seen annually. In addition to a detailed neurological examination, participants will receive a standardized battery of neuropsychological tests and will undergo genetic testing. The investigators will provide standardized periodic longitudinal assessment of the research participants. Autopsies to establish neurohistopathological diagnoses in clinically well-characterized patients with dementia, patients with mild MCI, and cognitively normal elderly control subjects will also be conducted.

Enrollment

900 estimated patients

Sex

All

Ages

50+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For patients with MCI, or dementia, the presence of cognitive deficits including memory, language, and executive function.

Exclusion criteria

Presence of non-neurological medical conditions interfering with cognition.